A Plague On Both Your Houses
Meaning
A curse on both sides of any argument given out in frustration.
Origin
It is believed to be originated from Shakespeare’s Romeo and Juliet, 1594:
MERCUTIO:
I am hurt.
A plague o’ both your houses! I am sped.
Is he gone, and hath nothing?
The houses are those of the feuding Montague and Capulet families, which caused Juliet so much grief and was the source of her ‘O Romeo, Romeo! wherefore art thou Romeo’ speech.